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Stress response pathways The expressions of various stress-related proteins, including heat-shock factor 1 (HSF1), heat-shock protein 90 (HSP90), heat-shock protein 27 (HSP27), and phosphorylated HSP27, and antioxidant enzymes, including superoxide dismutase 1 (SOD1), mitochondria SOD (SOD2), and phospholipid hydroperoxide glutathione peroxidase (GPx4), were measured among smokers and non-smokers

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