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The lack of nicotine takes most of the throat hit away, but even nicotine-free vapes can have a tiny bit of throat hit, usually those with a tight cigarette-like draw (MTL) and a propylene glycol content higher than 50%

Prevalence and correlates of smoking, drinking, and exercise among men in Dak Lak, Vietnam Khanh Nam Pham, Anh Tuan Truong, Quoc Nhat Nguyen Journal of Ethnicity in Substance Abuse 24

(ii) Onset of pain or discomfort associated with a change in frequency of stool (either more stools or fewer stools)