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Furthermore, MMPs via tissue remodeling and post-translation processing of SASP factors contribute to the initiation and progression of CVD and metastasis in cancer [18]

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Firstly, the sample of smokers was judiciously selected based on the geographical representation, but not a random sample of the entire smoking population in Shanghai, and the 1104 smokers in this study was a relatively smaller sample in comparison with the large number of tobacco smokers in Shanghai, which limited the generalization of findings in this study

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