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The mechanisms don't overlap

Lack of sleep affects hormones that control hunger, cravings, and appetite, which can make you eat more unhealthy foods during the day

The ClinicalTrials.gov registry shows multiple ongoing tirzepatide studies, but all focus on metabolic endpoints (weight loss, diabetes management, cardiovascular outcomes, obstructive sleep apnea) rather than autoimmune disease activity

The latest PBM coverage wins and LillyDirect partnerships meaningfully reduce access risk, but they do not remove pricing and policy pressure