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In the tumor microenvironment, macrophage phenotypic polarization exhibits significant functional differences, primarily classified into the M1 phenotype, which has tumor-suppressive effects, and the M2 phenotype, which promotes tumor development (74)

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332,386 The application of conventional -blockers should be considered cautiously if there is not a given essential indication, such as atrial fibrillation, or if tachyarrhythmia after myocardial infarction is prevented because of potential negative effects on PWV and central blood pressure levels

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