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The album earned Ronstadt another Grammy nomination for Best Female Pop Vocal Performance, and critical raves, with Time magazine calling it "one of the gutsiest, most unorthodox and unexpected albums of the year." Ronstadt faced considerable pressure not to record What's New or record with Riddle

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Additionally, the DEF/YxP motif (residues 134-138) at the C-terminal end of Syn is critical for anchoring to the histone H2a-H2b dimer

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However, these expression systems have significant limitations for commercial application including very high production cost and limited scalability [67]