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Over time, with continued heavy use, the hallucinogenic effects of the drug can also cause the development or worsening of mental health conditions such as anxiety and depression

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Microchem J 145:4246 Di Giacomo S, Mazzanti G, Di Sotto A (2016) Mutagenicity of cigarette butt waste in the bacterial reverse mutation assay: the protective effects of -caryophyllene and -caryophyllene oxide