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And, between mouthfuls of a burrito from a roadside burger stand, she expressed a desire to kick, for professional reasons: "I can sing better after shooting smack in both arms than after eating too much," she said

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Nicotine alone reduced ICSS thresholds at a moderate nicotine dose, suggesting a reinforcement-enhancing effect that may promote abuse liability, and elevated ICSS thresholds at a high nicotine dose, suggesting an aversive/anhedonic effect that may limit abuse liability