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to severe physical symptoms such as anemia, paralysis, dementia and other cognitive disorders

Research published by the National institute on Drug Abuse (NIDA) confirms that nicotine addiction alters brain structure and function in ways comparable to other substance use disorders

Regarding HTP, the Cochrane Tobacco Addiction Group carried out a systematic review on the efficacy of HTP for smoking cessation, but had to conclude that the HTP efficacy remains uncertain, since no studies have been done on this, even funded by the tobacco companies

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A total of 207 patients were found and they represented 7.2% of the 2881 patients globally examined for the first visit in the period of the study