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However, any effect during the study from participants resuming snus use would likely have attenuated the results and affected the trend in, e.g., home BP

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Toxicol Appl Pharmacol 226:1421 Barr D, Wilder L, Caudill S et al (2005) Urinary creatinine concentrations in the US population: implications for urinary biologic monitoring measurements

Caffeine has a median half-life of about 5 hours, although this can vary among individuals, especially in the case of pregnant women in the last trimester, where the half-life can inexplicably increase to 18 hours

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