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When taken for pain management, buprenorphine is placed in your cheek or given through an IV or skin patch

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In addition, the drug interferes with the metabolism of GABA, an important biochemical that helps us filter information and plan sensible action strategies.4 So the caffeine-stress combination, in effect, turns up the activity level in your brain while at the same time lowering your coping skills and decreasing your ability to relax

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