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Sleep deprivation also interferes with hunger-related hormonesinsulin, ghrelin and leptinleading to weight gain and insulin resistance, contributing to pre-diabetes and type 2 diabetes

How Genetic Testing Reveals Your Personalized GLP-1 Response The PlexusDx Precision Peptide Genetic Test analyzes GLP1R (rs6923761), GIPR (rs1800437), FTO (rs9939609), and MC4R (rs17782313) variants that relate to GLP-1 and related signaling pathways

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Further evidence for the importance of the microbiota for incretin regulation comes from germ-free (GF) and antibiotic-treated mice, which have severely reduced SCFA levels, and concomitantly increased basal GLP-1 plasma levels as well as increased proglucagon expression, specifically in the colon (35)

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