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In response to injury, tubular epithelial cells undergo structural and functional changes due to inflammatory and fibrogenic cells, with the consequent production of bioactive molecules that drive interstitial inflammation and fibrosis

It can be very general or get more detailed when we start including factors like the age at which a person began smoking, the volume they smoked during the time when they did, and the date when they quit, if thats something theyve done

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