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Wang et al., 2016

Author contributions AK, NM, KA, OA, MH, YY, RT, and SS: conceptualization, data curation, formal analysis, investigation, methodology, visualization, writingoriginal draft preparation, and writingreview and editing

MALE FERTILITY AND SPERMATOGENESIS Hypogonadotropic Hypogonadism: Steroidogenesis Restoration Serum testosterone: increase from 200 ng/dL above baseline Primary failure: no response (Leydig cell damage) Secondary failure: present response but low baseline Applications: Differentiation between primary and secondary hypogonadism Pre-pubertal Leydig cell reserve evaluation Treatment response prediction 5

The Gardos effect drives erythrocyte senescence and leads to Lu/BCAM and CD44 adhesion molecule activation

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