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Furthermore, quercetin counteracts ferroptosis under inflammatory conditions by modulating the IL-6/STAT3 pathway to regulate ferritinophagy and promote cellular iron export ( Baicalin, a flavonoid derived from the roots of Scutellaria baicalensis , possesses a broad spectrum of pharmacological effects, including anti-inflammatory, antitumor, antibacterial, lipid-lowering, and antioxidant activities (80)
Two consecutive reads were averaged
Since D2HG and L2HG are indistinguishable in standard LC-MS, to determine which 2HG enantiomer(s) is affected, we adapted a chiral N-(p-toluenesulfonyl)-L-phenylalanyl chloride (TSPC) derivation followed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis 24,40
