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Diabetes and obesity, both of which are associated with the secretion of pro-inflammatory adipokines and the reduced availability of nitric oxide, may lead to the occurrence of HFpEF in young individuals due to myocardial remodeling and fibrosis [7, 34]

This physical slowdown sends continuous signals to your brain that your stomach is full, overriding the scrambled leptin and ghrelin signals caused by sleep deprivation

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doi: 10.2478/raon-2018-0034 69 tamparPBlagusTGoriarKBogoviPTurelGStrleFet al