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51,52 S1P receptor modulators sequester subsets of lymphocytes in peripheral lymph nodes, preventing them from trafficking to areas of inflammation

Here's what's happening at the cellular level: Immune System Modulation : GLP-1 receptors are expressed on circulating T and B lymphocytes, human invariant natural killer T cells, and immature lymphocyte subsets, highlighting their role in lymphocyte maturation and regulatory T-cell functioning

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However, the dynamics of their interaction, particularly when used concurrently, is a topic of considerable interest and debate