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Avoid taking anti-inflammatory medications such as aspirin and ibuprofen for a few days before the procedure

Bacteriostatic water is commonly used for this process because it maintains a sterile environment while allowing accurate measurement of liquid volumes

A 2025 systematic review and meta-analysis in Frontiers in Pharmacology (Mazur and colleagues, 16 studies, 6,098 participants) found that oral, sublingual, and intramuscular B12 all raised serum cobalamin to a comparable degree, with no statistically significant difference between routes

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