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Initially derived from Melanotan IIa peptide known for its tanning effectsPT-141 was discovered to have significant potential in enhancing sexual desire, leading to its targeted use for libido enhancement

The primary mechanism is significant weight loss that reduces fat around the airway and abdomen

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Ertugliflozin use is contraindicated in patients with an estimated glomerular filtration rate (eGFR) less than 30 mL/minute/1.73 m 2 , and it is not recommended in those with an eGFR less than 60 mL/minute/1.73 m 2