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We evaluated respiration and reactive oxygen production rates, cyclosporine-A sensitive mitochondrial calcium release, antioxidant enzyme activities in liver mitochondria or homogenates obtained from LDLr -/- mice treated with pravastatin for 3 months

The first consists in the study of the expression of single candidate genes already known to be target of redox-regulation, such as cjun43 and NF-B.44 However, since it has been shown that the biological response due to oxidative stress is mediated by the modification of a complex array of genes,45 the study of single candidate genes may not be adequate to solve the complexity of oxidative-stress-based liver pathologies

doi: 10.1002/jlb.63.5.534 106 WolachBAshkenaziMGrossmannRGavrieliRFriedmanZBashanNet al

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PMID 8598105.