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Comput Theor Chem 1048:95101 Grune T, Reinheckel T, Li R, North JA, Davies KJ (2002) Proteasome-dependent turnover of protein disulfide isomerase in oxidatively stressed cells

Their half-lives are 13 hours (LIRA) and 7 days (SEMA), allowing for daily and weekly subcutaneous administration, respectively, thanks to the structural modifications introduced.5,10 Effects on obesity and glycaemic control Both LIRA 3 mg and SEMA 2.4 mg have demonstrated a strong appetite-suppressing and satiety-promoting effect, as well as a delaying effect on gastric emptying.11,12 The SCALE programme highlighted the efficacy of LIRA 3 mg in reducing body weight and waist circumference13 and confirmed a reduction in HbA1c levels in individuals with diabetes, along with a decreased progression from prediabetes to diabetes after three years of treatment14 (Table 1)

The current picture is mechanistically credible and supported by small-scale human data, not clinically definitive

Whats more, because GLP-1s are not banned, theres no need to name the others specifically while the advisory group collects data on how the market leader is being used, Rabin says

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