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Choosing Open will either launch your citation manager or give you a choice of applications with which to use the metadata

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(Figure 5E)

This seems like a minor detail until you realize that reading from the wrong edge of the stopper can shift your measurement by 1 to 2 units, enough to alter your dose meaningfully at higher concentrations

I can imagine some minor symptomatic ups and downs on the road to diagnosing such a cancer, the downward trend would be hard to miss steadily changing from annoying to downright unpleasant