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42 However, results from the SURMOUNT trial, a phase III RCT of tirzepatide, demonstrated that lean-mass reduction is approximately three times less than fat-mass reduction, contributing to an overall improvement in body composition

Based on the fascinating hostguest chemistry of Cucurbit uril [7] and the features of the inserted guest molecules, one may be able to build diverse stimuli-responsive gel systems by identifying the suitable guest molecules [303]

Comprehensive cardiometabolic improvements were observed including reductions in waist circumference, blood pressure, lipids, uric acid, liver fat content, and hepatic transaminases

The article adds that a qualified provider must also evaluate kidney function, gastrointestinal history, thyroid status, and cardiovascular risk profile beforehand