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Where this can get more complicated is in patients who have had mold exposure, thus reducing the immune protectivity of the gut lining, leading to bacterial and yeast overgrowthso they have both the infection and the mold exposure

For example, in the case of HIV, IgG3 has been shown to be generally more effective at neutralization than IgG1 of the same specificity, possibly related to the greater flexibility of IgG3 associated with a longer hinge region, which allows for more restricted epitopes to be accessed, although there are some exceptions 97,98,99,100

Others with broader metabolic issues may need different interventions entirely

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