The rationale for combining them, as explored in published research, is potential additive or synergistic engagement of these separate receptor systems
For instance, the use of glutathione for skin whitening via intravenous injection is banned or heavily warned against by the FDA in the US and health authorities in the Philippines due to safety risks, yet the practice persists in grey markets, posing a reputational risk to the ingredient
Diabetes (2010) 59(4):10307.10.2337/db09-1694 189 KuHCChenWPSuMJ
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These include deficiencies of vitamin B12, folate or niacin, and infective causes including cryptococcal meningitis, HIV, Lyme disease, progressive multifocal leukoencephalopathy, subacute sclerosing panencephalitis, syphilis and Whipple's disease