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Clinical trials demonstrate remarkable efficacy in treating withdrawal symptoms, with 97% of opiate-dependent and 87% of alcohol-dependent patients experiencing symptom relief

Valentini V, Cacciapaglia F, Frau R, Di Chiara G (2006) Differential alpha2-mediated inhibition of dopamine and noradrenaline release in the parietal and occipital cortex following noradrenaline transporter blockade

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In the book, Kessler acknowledges that you can't really separate those unpleasant feelings from the effective mechanism of the drugs themselves

For tirzepatide, restart at 2.5 mg weekly