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WHO Classification of Weight Status Medications approved for chronic weight management can be useful adjuncts to lifestyle modification for patients who have been unsuccessful with diet and exercise alone

GLP-1 RAs can provide clinically significant benefits at submaximal doses and should be taken at the maximal tolerated dose but should be discontinued if patients fail to achieve significant weight loss on this dose after six months

This, therefore, means adding B12 supplementation is important for health maintenance

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