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Blocking the IL-10 receptor enhances chemotherapy efficacy by restoring IL-12-mediated antitumor immunity

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Here, we have utilized liver-specific overexpression of cation transport regulator homolog 1 ( Chac1 ), a recently identified intracellular GSH-degrading enzyme, to induce hepatic GSH depletion during MASLD progression

The publication concluded that Supplementation with a combination of vitamin D and L-cysteine or glutathione precursor, rather than supplementation with vitamin D alone, is beneficial and helps achieve more successful vitamin D supplementation. Study Confirms Significant Effect of Vitamin D Level on Levels of Glutathione, GSSG, and Cysteine A study by Alvarez et al