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NICE recommends graded exercise programmes tailored to individual pain and fatigue levels, dietary interventions with dietitian support, psychological therapies such as CBT, and alternative medications like orlistat

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In addition, we observed that HIF-1 protein levels accumulate downstream of mTOR in response to GLP-1R signalling, whereas we also demonstrated that depletion of HIF-1 impaired effects on glycolysis and transcriptional regulation of glycolytic genes