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Administration, dosage, bioavailability and other aspects of glutathione therapy, as applied to the treatment of hyperpigmentation of skin, have not been examined systematically

In a suspected case of CPT II deficiency the following are considered: (1) dextrose infusion to prevent catabolism till special milk feeds can be arranged, (2) a high carbohydrate and low-fat diet to provide substrate for glycolysis, (3) avoidance of known triggers, e.g., fasting, illness etc., (4) urgent IEM screen/genetic testing/echocardiography/and ultrasound scan of the brain and kidneys, (5) MCT supplementation, (6) intensive care monitoring, and (7) a multidisciplinary team including metabolic specialists and palliative care doctors

Magi S, Preziuso A, Piccirillo S, Giampieri F, Cianciosi D, Orciani M, et al

Vitamin B6 (pyridoxine HCl) Vitamin B6 acts as a cofactor for enzymes involved in amino acid metabolism and neurotransmitter production

All subjects tolerated the GSSG lotion well and reported no untoward symptoms