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In research it serves as substrate for sirtuins (SIRT1-7), PARP enzymes and CD38, key regulators of cellular aging, DNA repair and metabolism

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They are also contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2, based on preclinical findings in rodent models

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A higher level of active GSH compared with GSSG generally indicates stronger antioxidant protection and a healthier cellular environment