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However, if you have not lost at least 5% of your original body weight after 12 weeks of using the maintenance dose, you should stop taking Semaglutide

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Semaglutide is primarily metabolised via proteolytic cleavage and beta-oxidation , pathways that do not heavily rely on hepatic cytochrome P450 enzymes

Microscopic molecular pores in the collecting ducts can selectively allow water to be pulled out of the ducts and retained in the body (Baynes 2014