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The highest dose of 4.5 mg produced an average weight loss of 11.5 kg, roughly 25 pounds, in just 26 weeks

[17] [18] Glibenclamide may occasionally be considered under specialist supervision when other options are unsuitable, with careful monitoring of the infant for signs of hypoglycaemia (poor feeding, jitteriness, unusual sleepiness)

For semaglutide , a phase 2 trial published in the New England Journal of Medicine (2021) examined daily semaglutide 0.4 mg in NASH patients and found that 59% achieved NASH resolution compared to 17% with placebo

[2] Clin Endocrinol (Oxf)