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To explore this idea, we bred the MMTV-PyMT transgenic mouse strain (which spontaneously develops breast tumours) 26 with an uninduced Gclc f/f Rosa26 creERT2 mouse 27 in which the rate-limiting step in GSH synthesis, the glutamatecysteine ligase catalytic subunit (GCLC), can be knocked out throughout the body after induction with tamoxifen

These findings have been interpreted as suggesting potential protective cellular processes, though precise implications remain under review

There have not been any clinical trials conducted to test the effect of N-acetylcysteine on any of the spinocerebellar ataxias