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Phase 2 CagriSema in T2D (Frias et al., 2023): CagriSema produced superior weight loss and glycemic improvement vs either monotherapy over 32 weeks

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On the basis of the dosing conditions trial, which was completed at the time of planning the food-effect trial, it was assumed that the standard deviation for the log-transformed AUC 024h,semaglutide,day10 was 0.60

The same group of patients exhibited elevated ALT but reduced APAP glucuronide levels, suggesting that UGT1A6*2 polymorphism is a modifier of acetaminophen glucuronidation in patients with abnormal liver function

Dungan KM, Povedano ST, Forst T, et al