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For example, mutations in the p53 tumor suppressor gene, often caused by oxidative stress, are frequently observed in various cancers [99]

J Prev Med Public Health

Impaired immune function, peripheral neuropathy, glossitis (swollen tongue), and skin conditions

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This discovery represented a major advance in understanding enzymatic antioxidant defence mechanisms and highlighted the biological importance of selenium, which was later recognised as an essential trace element due to its role in selenoproteins such as GPx