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In SOD1 mouse models, endplate denervation was seen prior to clinical weakness and motor neuron loss, suggesting that NMJ compromise occurs early in the pathophysiology of ALS and is often the inciting event prior to lower motor neuron injury (dying back hypothesis) [283]

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The phenolic hydroxyl group derived from the tyrosine fragment may be sensitive to oxidative conditions

[1] Las increntinas a travs de GPCR y Gs aumentan el AMPc, que activa pkA, la cual potencia la desgranulacin de los grnulos de insulina