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[14] Small clinical trials indicate that maternal supplementation of 4,000 IU day or staggered 50,000 IU oral doses can safely maintain 25-hydroxyvitamin D above 30 ng mL without inducing hypercalcaemia, whereas single injections of 300,000 IU are reserved for severe malabsorption emergencies when benefits outweigh theoretical teratogenic risk

Matsuzaki, K., Biochim

Mitochondrially derived peptides as novel regulators of metabolism

According to the brand's published documentation, the arginate salt offers greater stability in the gastrointestinal environment compared to acetate, and this was the deliberate formulation choice made to support consistency and potency in capsule delivery.* That rationale is stated by the brand and reflected on the product page

The key is to approach each one with the same rigorous, safety-first mindset