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While members of this family carry an autosomal dominant APP duplication rearrangement that leads to early-onset familial AD, including pre-symptomatic (do not fulfill yet the diagnostic criteria) and symptomatic (with clinically diagnosed AD) patients, subjects from the same family in which the genetic testing did not show the APP duplication were considered as non-carrier healthy controls

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Pallotta V, Gevi F, DAlessandro A, Zolla L (2014) Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview