Antagonism of Dopamine 2 (D2) receptors in the mesolimbic pathway may lead to dysregulated eating by opposing the effects of pre-synaptic dopamine release within neurons connecting the ventral tegmental area to the nucleus accumbens involved in mediating satiety following food intake ( However, antipsychotics with selective activity at D2 receptors through partial agonism (e.g., aripiprazole) or antagonism (e.g., amisulpride) are uncommonly associated with clinically significant AIWG ( Metformin interference with mechanisms mediating AIWG The capacity of metformin to attenuate AIWG lies in its ability to oppose both hyperphagia and reduced satiety induced by antipsychotic treatment
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clitoris, penis), increasing sexual arousal, orgasm, and secondarily by reinforcement and reward, sexual desire, as predicted by the purple line in Fig
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