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In vertebrates, axonal guidance during embryonic development and regeneration depends on extracellular signaling molecules

When severed nerves in animal models were placed in collagen tubes impregnated with GHK, researchers observed significantly increased nerve outgrowth, elevated production of nerve growth factor (NGF) and neurotrophins NT-3 and NT-4, accelerated regeneration of nerve fibers, and increased axon count and Schwann cell proliferation compared to controls

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