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Johansson GS, Chisalita SI, Arnqvist HJ: Human microvascular endothelial cells are sensitive to IGF-I but resistant to insulin at the receptor level

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A key challenge in studying native GLP-1 is its extremely short in vivo half-life of approximately 12 minutes, owing to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), which cleaves the N-terminal His-Ala dipeptide from GLP-1 to produce the inactive metabolite GLP-1(936)amide