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Encinas JM, Vaahtokari A, Enikolopov G

So the team created a device that can deliver aerosolized medication using 3D printed parts, a soda bottle and a bike pump

If side effects appear at a higher dose, return to the previously tolerated dose

The reason for this unexpected observation was that paralysis of an essential cellular defense mechanism like autophagy leads to faster accumulation of cellular waste, which triggers an enhanced rate of cell turnover through apoptosis and compensated enhanced regeneration [151]

Mechanistically, dietary spermidine crosses the blood-brain barrier in mice, increasing hypusination of eukaryotic translation initiation factor 5A (EIF5A) and mitochondrial function in the hippocampus while reducing mitochondrial decay