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A study by Stanley and colleagues evaluated tesamorelin in overweight and obese adults without HIV and found significant VAT reductions, improvements in triglycerides, and increased IGF-1 mirroring the HIV-trial outcomes.[4] This is directly relevant for patients with metabolic syndrome and abdominal obesity who share the underlying pattern: suppressed GH-axis activity, excess visceral fat, dyslipidemia, and insulin resistance

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Conversely, gut dysbiosis can induce immunological activation that enhances osteoclast activity and accelerates bone resorption

Psychiatry 47, 4860

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