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Acknowledgements and funding The authors work on gut-derived hormones and obesity-diabetes has been generously supported over many years by Diabetes UK, Invest Northern Ireland, the Irish Endocrine Society, Northern Ireland Department for the Economy, and Ulster University Strategic Funding

Semaglutide While past research has shown tirzepatide produces greater weight loss than semaglutide in patients with type 2 diabetes, data from head-to-head trials comparing these medications in patients without diabetes are not yet available

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Your experience with feeling hot and tingly, almost like you've already started working out, is actually a common sign that the thermogenic effects are kicking in