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SURPASS-2, NEJM 2021 An important caveat: semaglutides proven cardiovascular benefit is a meaningful clinical differentiator
Common side effects of metformin Metformin can also cause: Nausea Diarrhoea Stomach upset Metallic taste Managing gastrointestinal side effects Since both medications can affect your gut, here are some practical tips: Eat 3 main meals a day, with snack in between Base your meals on whole foods and minimise ultra-processed foods and take-aways Stay well hydrated, this is especially important to protect your kidneys Take metformin with food to reduce stomach upset Be patient as symptoms usually improve within the first few weeks When to contact your doctor Seek medical advice if you experience: Severe or persistent nausea and vomiting Signs of dehydration (dark urine, dizziness, dry mouth) Severe abdominal pain that could indicate pancreatitis Signs of an allergic reaction (rash, swelling, difficulty breathing) Symptoms of low blood sugar if taking other diabetes medications Dosing and monitoring How Mounjaro is dosed Mounjaro is started at a low dose and gradually increased to minimise side effects: Starting dose: 2.5 mg once weekly for 4 weeks First increase: 5 mg once weekly Further increases: Can be increased by 2.5 mg every 4 weeks Maintenance doses: 5 mg, 10 mg, or 15 mg once weekly Your doctor will determine the correct maintenance dose based on your blood sugar response and how well you tolerate the medication
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The drug could also aggravate pre-existing kidney concerns and in some cases, induce tumours in the thyroid, including thyroid cancer
