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Increased heart rate is a recognised effect, with clinical trials showing a mean increase of approximately 2-3 beats per minute

Mao Q, Min J, Zeng R, Liu H, Li H, Zhang C, et al

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One hypothesis posits that pressor effects are mediated by the activation of central MC receptors but not peripheral, supported by observed cardiac effects after central -MSH administration but not when -MSH is delivered intravenously (152)

This study was supported by the EHA Ukraine Bridge Funding awarded by the European Hematology Association, Ministry of Health of the Czech Republic (DRO - VFN00064165), National Institute for Cancer Research (EXCELES - LX22NPO5102), Ministry of Education, Youth, and Sports of the Czech Republic via Charles University (Cooperatio Program, research area Biology)