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Non-clinical PK/PD modeling facilitates the selection of doses for the FIH trial

They often involve hours of standing, loud environments, alcohol, and late nights

Subcutaneous vs Intramuscular Injection: Site-Specific Research Considerations Beyond the general pharmacokinetic differences, specific injection sites within each route category can affect peptide research outcomes

Other mouse strains such as C3H or BALB/c would be the next option though some aspects of human pathophysiology may not be replicated in these strains