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Experimental Results: Bone mineral density (BMD): OVX control group: Lumbar BMD decreased by 28% and hip BMD decreased by 25% compared to Sham group (successful osteoporosis model)

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In addition, pharmacological intervention with SAHA also restored the histone H3 acetylation level, reversed pathological form of synaptic plasticity, and abrogated the epileptic phenotype in the TSC2 +/ mice showing the neurological manifestations including seizures, autism and cognitive deficits [138]

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