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They also provide important real-world constraints: even with relatively simple compositions and a limited number of quality attributes, the magnitude of clinical benefit tends to be moderate

Fluoxetine is a potent inhibitor of the liver enzyme CYP2D6, which metabolises bupropion

On average, RA disease activity scores decreased while controls experienced a slight worsening

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Thus, allosteric inhibition by juglone also seemed unlikely from these observations (Video S2)